王洁

姓名

王洁

性别

女

邮箱地址

wangjielangjing@126.com

通讯地址

广东广州天河区五山路483号版权所有 beat·365(中国)在线体育415室

职称

副研究员

所在院系

beat365中国在线体育生物工程系

个人简介

王洁，女，博士，副研究员，硕士生导师，主要从事微生物代谢、微生物基因功能分析及遗传改造、食品功能成分的健康功效及生物转化、食品微生物资源与利用相关研究。近五年主持及参与多项省部级以上科研项目，在Environmental Microbiology 、Applied Microbiology and Biotechnology、Fungal Genetics and Biology、European Journal of Pharmacology等期刊上以第一作者或通讯作者发表SCI论文十余篇，申请国家发明专利3项。

研究方向

1. 微生物代谢，包括活性成分的分离鉴定及其生物合成、食品功能成分如多酚黄酮的生物转化及毒性成分如真菌毒素的减毒等；

2. 功能微生物及其功能基因分析与遗传改造

3. 功能组分的健康功效及其分子机理

承担教学

《食品微生物学》、《食品微生物学实验技术》、《微生物制剂》

科研项目

1、国家自然科学青年基金，聚酮合酶pks7和pks11对海洋草酸青霉合成Oxalicumone A及其环境适应性的调控机制研究，2017.01-2019.12，主持，已结题

2、广州市科技计划项目，抗MRSA抗菌肽的结构鉴定、抑菌机理及其在肉制品保藏中的应用潜能评估，2019.04-2022.03，主持，在研

3、华南应用微生物国家重点实验室开放课题，抗铜绿假单胞菌抗菌肽的结构鉴定及抑菌机理，2019.09-2021.08，主持，在研

4、广东省重点领域研发计划项目，发酵食品精准制造关键技术及产业化示范，2019.11-2024.10，参加，在研

5、广东省重点领域研发计划项目，特色微生物航天育种技术创新与菌种创制，2019.01-2021.12，参加，在研

学术论文

1. Fang X, Du M, Liu T, Fang Q, Liao Z, Zhong Q, Chen J, Meng X, Zhou S, Wang J*. 2019. Changes in the biotransformation of green tea catechins induced by different carbon and nitrogen sources in Aspergillus niger RAF106. Frontiers in Microbiology 10: 2521.

2. Zhou G, Ying S, Hu Y, Fang X*, Feng MG*, Wang J*. 2018. Roles of three HSF domain-containing proteins in mediating heat-shock protein genes and sustaining asexual cycle, stress tolerance, and virulence in Beauveria bassiana. Frontiers in Microbiology 9:1677.

3. Wang J, Nong X, Amin M , Qi S*. 2018. Hygrocin C from marine-derived Streptomyces sp. SCSGAA 0027 inhibits biofilm formation in Bacillus amyloliquefaciens SCSGAB0082 isolated from South China Sea gorgonian. Applied Microbiology and Biotechnology 102: 1417-1427.

4. Wang J，Zhong Q, Yang Y, Li H, Wang L, Tong Y, Fang X*, Liao Z*. 2018. Comparison of bacterial diversity between two traditional starters and the Round-Koji-Maker starter for traditional cantonese Chi-flavor liquor brewing. Frontiers in Microbiology 9:1053.

5. Wang J, Ying S, Hu Y, Feng MG*. 2017. Vital role for the J-domain protein Mdj1 in asexual development, multiple stress tolerance, and virulence of Beauveria bassiana. Applied Microbiology and Biotechnology 101:185-195.

6. Wang J, Zhu X, Ying S, Feng MG*. 2017. Differential roles for six P-type calcium ATPases in sustaining intracellular Ca²⁺ homeostasis, asexual cycle and environmental fitness of Beauveria bassiana. Scientific reports 7: 1420.

7. Wang J, Yao Q, Amin M, Nong X, Zhang X, Qi S*. 2017. Penicillenols from a deep-sea fungus Aspergillus restrictus inhibit Candida albicans biofilm formation and hyphal growth. The Journal of Antibiotics 70: 763-770.

8. Wang J, Nong X, Zhang X, Xu X, Amin M, Qi S*. 2017. Screening of anti-biofilm compounds from marine-derived fungi and the effects of secalonic acid D on Staphylococcus aureus biofilm. Journal of Microbiology and Biotechnology 27: 1078-1089.

9. Wang J, Wang QL, Nong XH, Zhang XY, Xu XY, Qi SH*, Wang YF. 2016. Oxalicumone A, a new dihydrothiophene-condensed sulfur chromone induces apoptosis in leukemia cells through endoplasmic reticulum stress pathway. European Journal of Pharmacology 783: 47-55.

10. Wang J, Ying S, Hu Y, Feng MG*. 2016. Mas5, a homolog of bacterial DnaJ, is indispensable for the host infection and environmental adaptation of a filamentous fungal insect pathogen. Environmental Microbiology 18: 1037-1047.

11. Wang J, Zhou G, Ying SH, Feng MG*. 2014. Adenylate cyclase orthologues in two filamentous entomopathogens contribute differentially to growth, conidiation, pathogenicity and multi-stress responses. Fungal Biology 118: 422-431.  

12. Hu Y#, Wang J#, Ying SH, Feng MG*. 2014. Five vacuolar Ca²⁺ exchangers play different roles in calcineurin-dependent Ca²⁺/Mn²⁺ tolerance, multistress responses and virulence of a filamentous entomopathogen. Fungal Genetics and Biology 73: 12-19.

13. Wang J, Liu J, Hu Y, Ying SH, Feng MG*. 2013. Cytokinesis-required Cdc14 is a signaling hub of asexual development and multi-stress tolerance in Beauveria bassiana. Scientific reports 3:3086.

14. Wang J, Zhou G, Ying SH, Feng MG*. 2013. P-type calcium ATPase functions as a core regulator of Beauveria bassiana growth, conidiation and responses to multiple stressful stimuli through cross-talk with signalling networks. Environmental Microbiology 15: 967-979.

15. 杜敏如, 房倩安, 廖振林, 方祥*, 王洁*. 微生物介导的表没食子儿茶素没食子酸酯生物转化及其代谢物活性研究进展. 2020. 食品科学 41: 204-210

获奖情况

无

专利

1. 王洁，刘付茵，钟雪韵，周楚婷，房倩安，方祥. 一种复合生物保鲜剂及其应用. CN201911222220.8

2.王洁，房倩安，方祥，廖振林，钟青萍. 一株用于降解黄曲霉毒素B1的暹罗芽孢杆菌WF2019菌株及其应用. CN201910808563.6

3. 王洁, 方祥, 杜敏如, 郑勇, 廖振林. 一种儿茶素生物转化营养液及一种促进儿茶素生物转化的方法. CN201810805249.8